STAT1 deficiency underlies a proinflammatory imprint of naive CD4⁺ T cells in spondyloarthritis.

ABSTRACT:

Introduction

In spondyloarthritis (SpA), an increased type 3 immune response, including T helper cells (Th) 17 excess, is observed in both human and SpA animal models, such as the HLA-B27/human β2-microglobulin transgenic rat (B27-rat).

Methods

To investigate this unexplained Th17-biased differentiation, we focused on understanding the immunobiology of B27-rat naive CD4⁺ T cells (Tn).

Results

We observed that neutrally stimulated B27-rat Tn developed heightened Th17 profile even before disease onset, suggesting an intrinsic proinflammatory predisposition. In parallel with this observation, transcriptomic and epigenomic analyses showed that B27-rat Tn exhibited a decreased expression of Interferon/Th1- and increased expression of Th17-related genes. This mol

SUBMITTER: Cherqaoui B 

PROVIDER: S-EPMC10619905 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature