Connectivity patterns of the core resting-state networks associated with apathy in late-life depression.

ABSTRACT:

Background

Apathy is associated with reduced antidepressant response and dementia in late-life depression (LLD). However, the functional cerebral basis of apathy is understudied in LLD. We investigated the functional connectivity of 5 resting-state networks (RSN) hypothesized to underlie apathy in LLD.

Methods

Resting-state functional MRI data were collected from individuals with LLD who did not have dementia as well as healthy older adults between October 2019 and April 2022. Apathy was evaluated using the diagnostic criteria for apathy (DCA), the Apathy Evaluation Scale (AES) and the Apathy Motivation Index (AMI). Subnetworks whose connectivity was significantly associated with each apathy measure were identified via the threshold-free network-based statistics. Regions tha

SUBMITTER: Roy JC 

PROVIDER: S-EPMC10620011 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature