Structure and electromechanical coupling of a voltage-gated Na⁺/H⁺ exchanger.

ABSTRACT: Voltage-sensing domains control the activation of voltage-gated ion channels, with a few exceptions¹. One such exception is the sperm-specific Na⁺/H⁺ exchanger SLC9C1, which is the only known transporter to be regulated by voltage-sensing domains^2-5. After hyperpolarization of sperm flagella, SLC9C1 becomes active, causing pH alkalinization and CatSper Ca²⁺ channel activation, which drives chemotaxis^2,6. SLC9C1 activation is further regulated by cAMP^2,7, which is produced by soluble adenyl cyclase (sAC). SLC9C1 is therefore an essential component of the pH-sAC-cAMP signalling pathway in metazoa^8,9, required for sperm motility and fertilization⁴. Despite its importance, the molecular basis of

SUBMITTER: Yeo H 

PROVIDER: S-EPMC10620092 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature