Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to develop targeted therapies still need to be established. Some oncogenic mechanisms in PDAC carcinogenesis harness the EGFR/ERBB receptor family. To explore the effects on pancreatic lesions, we attempted simultaneous blockade of all ERBB ligands in a PDAC mouse model. To this end, we engineered a molecular decoy, TRAP-F_C , comprising the ligand-binding domains of both EGFR and ERBB4 and able to trap all ERBB ligands. Next, we generated a transgenic mouse model (CBA^TRAP/0 ) expressing TRAP-F_C ubiquitously under the control of the chicken-beta-actin promoter and crossed these mice with KRAS^G12D/+ mice (Kras) to generate Trap/Kras mice. The resulting mice displaye

SUBMITTER: Hedegger K 

PROVIDER: S-EPMC10620123 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature