Relationship of Klotho with cognition and dementia: Results from the NHANES 2011-2014 and Mendelian randomization study.

ABSTRACT: The relationships of Klotho levels with cognition and dementia are poorly understood. This study aimed to investigate the association between Klotho levels and cognitive function and to determine causality between Klotho and dementia using Mendelian randomization (MR). Based on data from the National Health and Nutrition Survey (NHANES) 2011-2014, this study consisted of 1875 older adults aged 60-79 years. Cognitive function was assessed by the digit symbol substitution test (DSST). We performed weighted multivariable-adjusted linear regression to assess the association between Klotho concentrations and cognitive function. Then, 2-sample MR was conducted to assess the causal relationship between Klotho and dementia. The inverse variance weighted (IVW) method was used as the primary analysi

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10620156 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature