Discovery of isoflavone phytoalexins in wheat reveals an alternative route to isoflavonoid biosynthesis.

ABSTRACT: Isoflavones are a group of phenolic compounds mostly restricted to plants of the legume family, where they mediate important interactions with plant-associated microbes, including in defense from pathogens and in nodulation. Their well-studied health promoting attributes have made them a prime target for metabolic engineering, both for bioproduction of isoflavones as high-value molecules, and in biofortification of food crops. A key gene in their biosynthesis, isoflavone synthase, was identified in legumes over two decades ago, but little is known about formation of isoflavones outside of this family. Here we identify a specialized wheat-specific isoflavone synthase, TaCYP71F53, which catalyzes a different reaction from the leguminous isoflavone synthases, thus revealing an alternative pat

SUBMITTER: Polturak G 

PROVIDER: S-EPMC10620232 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature