Thigh muscle fat fraction is independently associated with impaired glucose metabolism in individuals with obesity.

ABSTRACT:

Background

The aim of this study was to address the intramuscular adipose tissue (IMAT) accumulation in the lower extremities and further detect the relationship between adipose tissue (AT) distribution in the muscle and glucose metabolism in subjects with obesity.

Methods

We conducted a cross-sectional study in 120 Chinese obese adults (80 male and 40 female) with BMI ≥ 28 kg/m2. MRI was applied to access the IMAT content in lower extremities. The oral glucose tolerance test was used to evaluate the glucose metabolism and insulin secretion in all individuals. The correlations between glucose metabolism and the fat content of the lower extremities were further assessed.

Results

Among 120 included subjects, 54 were classified as subjects with normal glucose tolerance (

SUBMITTER: Lu X 

PROVIDER: S-EPMC10620449 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature