Natural history and surgical outcome of incidentally discovered clinically nonfunctioning pituitary macroadenomas.

ABSTRACT:

Objectives

The incidental diagnosis of nonfunctioning pituitary macroadenomas (NFPMAs) is becoming more prevalent with the spread of modern brain imaging techniques. We sought to uncover new data about their natural history and surgical outcome.

Design

This is a retrospective single-center observational study.

Methods

Among 210 patients seen for a NFPMA between 2010 and 2019, 70 (33%) were discovered incidentally (i-NFPMA). We analyzed outcomes in a total of 65 patients with available follow-up data.

Results

Mean age at diagnosis (± s.d.) was 60 ± 14 years and mean maximal diameter was 20.0 ± 7.3 mm. At diagnosis, 29 patients (45%) had pituitary hormone deficits (LH/FSH 41%, TSH 29%, ACTH 15%) and 12% had visual field deficits. 26 patients underwent initial sur

SUBMITTER: Constantinescu SM 

PROVIDER: S-EPMC10620450 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature