RET fusion genes in pediatric and adult thyroid carcinomas: cohort characteristics and prognosis.

ABSTRACT: Thyroid cancer is associated with a broad range of different mutations, including RET (rearranged during transfection) fusion genes. The importance of characterizing RET fusion-positive tumors has recently increased due to the possibility of targeted treatment. The aim of this study was to identify RET fusion-positive thyroid tumors, correlate them with clinicopathological features, compare them with other mutated carcinomas, and evaluate long-term follow-up of patients. The cohort consisted of 1564 different thyroid tissue samples (including 1164 thyroid carcinoma samples) from pediatric and adult patients. Samples were analyzed for known driver mutations occurring in thyroid cancer. Negative samples were subjected to extensive RET fusion gene analyses using next-generation sequencing and

SUBMITTER: Bulanova Pekova B 

PROVIDER: S-EPMC10620462 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature