Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.

ABSTRACT:

Importance

Adverse life experiences have been proposed to contribute to diverse mental health problems through an association with corticolimbic functioning. Despite compelling evidence from animal models, findings from studies in humans have been mixed; activation likelihood estimation (ALE) meta-analyses have failed to identify a consistent association of adverse events with brain function.

Objective

To investigate the association of adversity exposure with altered brain reactivity using multilevel kernel density analyses (MKDA), a meta-analytic approach considered more robust than ALE to small sample sizes and methodological differences between studies.

Data sources

Searches were conducted using PsycInfo, Medline, EMBASE, and Web of Science from inception through M

SUBMITTER: Hosseini-Kamkar N 

PROVIDER: S-EPMC10620621 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature