The BioRef Infrastructure, a Framework for Real-Time, Federated, Privacy-Preserving, and Personalized Reference Intervals: Design, Development, and Application.

ABSTRACT:

Background

Reference intervals (RIs) for patient test results are in standard use across many medical disciplines, allowing physicians to identify measurements indicating potentially pathological states with relative ease. The process of inferring cohort-specific RIs is, however, often ignored because of the high costs and cumbersome efforts associated with it. Sophisticated analysis tools are required to automatically infer relevant and locally specific RIs directly from routine laboratory data. These tools would effectively connect clinical laboratory databases to physicians and provide personalized target ranges for the respective cohort population.

Objective

This study aims to describe the BioRef infrastructure, a multicentric governance and IT framework for the estimati

SUBMITTER: Blatter TU 

PROVIDER: S-EPMC10620636 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature