Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes.

ABSTRACT:

Importance

Posttraumatic stress disorder (PTSD) has been reported to be a risk factor for several physical and somatic symptoms. However, the genetics of PTSD and its potential association with medical outcomes remain unclear.

Objective

To examine disease categories and laboratory tests from electronic health records (EHRs) that are associated with PTSD polygenic scores.

Design, setting, and participants

This genetic association study was conducted from July 15, 2021, to January 24, 2023, using EHR data from participants across 4 biobanks. The polygenic scores of PTSD symptom severity (PGS-PTSD) were tested with all available phecodes in Vanderbilt University Medical Center's biobank (BioVU), Mass General Brigham (MGB), Michigan Genomics Initiative (MGI), and UK Bioba

SUBMITTER: Pathak GA 

PROVIDER: S-EPMC10620678 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature