The causality between gut microbiome and anorexia nervosa: a Mendelian randomization analysis.

ABSTRACT:

Background and aim

Nutrient production by intestinal microbiota corresponds to regulate appetite while gut microbial composition was influenced by diet ingestion. However, the causal relationship between gut microbial taxa and anorexia nervosa (AN) remains unclear. Mendelian Randomization (MR) is a novel research method that effectively eliminates the interference of confounding factors and allows for the exploration of the direct causal effects between exposure and outcome. This study employs MR to explore the causal effect between AN and specific gut microbiome.

Methods

Large-scale Genome Wide Association Study (GWAS) data of AN and 211 gut microbes were obtained from the IEU open GWAS project and Mibiogen Consortium. Two-sample MR was performed to determine the causal rel

SUBMITTER: Xia X 

PROVIDER: S-EPMC10620704 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature