Causal effects of gut microbiota on erectile dysfunction: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Several observational studies have reported the correlation between gut microbiota and the risk of erectile dysfunction (ED). However, the causal association between them remained unestablished owing to intrinsic limitations, confounding factors, and reverse causality. Therefore, the two-sample Mendelian randomization (MR) study was performed to determine the causal effect of gut microbiota on the risk of ED.

Methods

The MR analysis utilized the publicly available genome-wide association study (GWAS) summary-level data to explore the causal associations between gut microbiota and ED. The gut microbiota data were extracted from the MiBioGen study (N = 18,340), and the ED data were extracted from the IEU Open GWAS (6,175 ED cases and 217,630 controls). The si

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10620728 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature