IGFBP2 from a novel copper metabolism-associated biomarker promoted glioma progression and response to immunotherapy.

ABSTRACT:

Introduction

Copper metabolism encompasses all cellular metabolic processes involving copper ions and plays a significant role in the pathogenesis of diseases, including cancer. Furthermore, copper is intricately involved in various processes related to nucleotide metabolism. However, a comprehensive analysis of copper metabolism in gliomas remains lacking despite its importance.

Methods

To address this gap, glioma patients were stratified based on the expression levels of copper metabolism-related genes. By utilizing machine learning techniques, a novel copper metabolism-associated biomarker was developed. The potential of this biomarker in prognosis, mutation analysis, and predicting immunotherapy response efficiency in gliomas was systematically investigated.

Results</

SUBMITTER: Luo Q 

PROVIDER: S-EPMC10620745 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature