Enteroendocrine cells and gut hormones as potential targets in the crossroad of the gut-kidney axis communication.

ABSTRACT: Recent studies suggest that disruptions in intestinal homeostasis, such as changes in gut microbiota composition, infection, and inflammatory-related gut diseases, can be associated with kidney diseases. For instance, genomic investigations highlight how susceptibility genes linked to IgA nephropathy are also correlated with the risk of inflammatory bowel disease. Conversely, investigations demonstrate that the use of short-chain fatty acids, produced through fermentation by intestinal bacteria, protects kidney function in models of acute and chronic kidney diseases. Thus, the dialogue between the gut and kidney seems to be crucial in maintaining their proper function, although the factors governing this crosstalk are still emerging as the field evolves. In recent years, a series of studie

SUBMITTER: Nery Neto JAO 

PROVIDER: S-EPMC10620747 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature