Novel Quinoline-Based Thiosemicarbazide Derivatives: Synthesis, DFT Calculations, and Investigation of Antitubercular, Antibacterial, and Antifungal Activities.

ABSTRACT: The discovery of new antimicrobial agents as a means of treating drug-resistant microbial pathogens is of utmost significance to overcome their immense risk to human well-being. The current investigation involves the development, synthesis, and assessment of the antimicrobial efficacy of novel quinoline derivatives incorporating a thiosemicarbazide functionality. To design the target compounds (QST1-QST14), we applied the molecular hybridization approach to link various thiosemicarbazides to the quinoline core with a sulfonyl group. Upon the synthesis and completion of structural characterization via spectroscopic techniques (¹H NMR, ¹³C NMR, ¹⁵N NMR, IR, and HRMS), the title molecules were extensively evaluated for their potential antitubercu

SUBMITTER: Ozcan E 

PROVIDER: S-EPMC10620885 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature