Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.

ABSTRACT:

Background

The timings of reproductive life events have been examined to be associated with various psychiatric disorders. However, studies have not considered the causal pathways from reproductive behaviors to different psychiatric disorders. This study aimed to investigate the nature of the relationships between five reproductive behaviors and twelve psychiatric disorders.

Methods

Firstly, we calculated genetic correlations between reproductive factors and psychiatric disorders. Then two-sample Mendelian randomization (MR) was conducted to estimate the causal associations among five reproductive behaviors, and these reproductive behaviors on twelve psychiatric disorders, using genome-wide association study (GWAS) summary data from genetic consortia. Multivariable MR was th

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10621101 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature