High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages.

ABSTRACT:

Background

Epidemiological studies have demonstrated that individuals with preexisting conditions, including diabetes mellitus (DM), are more susceptible to air pollution. However, the underlying mechanisms remain unclear. In this study, we proposed that a high glucose setting enhances ambient fine particulate matter (PM_2.5)-induced macrophage activation and secretion of the proinflammatory cytokine, IL-1β, through activation of the NLRP3 inflammasome, altering the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs).

Results

Exposure of mouse alveolar macrophages to non-cytotoxic doses of PM_2.5 led to upregulation of IL-1β, activation of the NLRP3 inflammasome, increased nuclear translocation of the transcription facto

SUBMITTER: Mo Y 

PROVIDER: S-EPMC10621103 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature