A potential Chinese medicine monomer against influenza A virus and influenza B virus: isoquercitrin.

ABSTRACT:

Background

Influenza viruses, especially Influenza A virus and Influenza B virus, are respiratory pathogens and can cause seasonal epidemics and pandemics. Severe influenza viruses infection induces strong host-defense response and excessive inflammatory response, resulting in acute lung damage, multiple organ failure and high mortality. Isoquercitrin is a Chinese medicine monomer, which was reported to have multiple biological activities, including antiviral activity against HSV, IAV, SARS-CoV-2 and so on. Aims of this study were to assess the in vitro anti-IAV and anti-IBV activity, evaluate the in vivo protective efficacy against lethal infection of the influenza virus and searched for the more optimal method of drug administration of isoquercitrin.

Methods

In vitro infec

SUBMITTER: Luo R 

PROVIDER: S-EPMC10621105 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature