Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections.

ABSTRACT:

Background

Sepsis is a life-threatening organ dysfunction caused by abnormal immune responses to various, predominantly bacterial, infections. Different bacterial infections lead to substantial variation in disease manifestation and therapeutic strategies. However, the underlying cellular heterogeneity and mechanisms involved remain poorly understood.

Methods

Multiple bulk transcriptome datasets from septic patients with 12 types of bacterial infections were integrated to identify signature genes for each infection. Signature genes were mapped onto an integrated large single-cell RNA (scRNA) dataset from septic patients, to identify subsets of cells associated with different sepsis types, and multiple omics datasets were combined to reveal the underlying molecular mechanisms

SUBMITTER: Sun P 

PROVIDER: S-EPMC10621118 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature