Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis.

ABSTRACT:

Background

Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development. We hypothesize that local adaptation to light environments during human migration played a role in shaping the genetic basis of myopia, and we aim to investigate how the environment influences the genetic basis of myopia.

Method

We utilized the whole-genome variant data of the 1000 Genomes Project for analysis. We searched myopia-associated loci that were under selection in Europeans using population branch statistics and the number of segregating sites by length statistics. The outliers of these statistics were enriched in the Kyoto Encyclopedia of Genes and Genomes pathwa

SUBMITTER: Xia T 

PROVIDER: S-EPMC10621121 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature