Comparative clinical significance and biological roles of PFKFB family members in oral squamous cell carcinoma.

ABSTRACT:

Background

Cancer cells promote glycolysis, which supports rapid cell growth and proliferation. Phosphofructokinase-fructose bisphosphatases (PFKFBs), a family of bidirectional glycolytic enzymes, play key roles in the regulation of glycolysis in many types of cancer. However, their roles in oral squamous cell carcinoma (OSCC), the most common type of oral cancer, are still unknown.

Methods

We compared the gene expression levels of PFKFB family members and analyzed their clinical significance in oral cancer patients, whose clinical data were obtained the Cancer Genome Atlas database. Moreover, real-time quantitative polymerase chain reaction, western blotting, assays for cell viability, cell cycle, cell migration and viability of cell spheroid were performed in scramble and

SUBMITTER: Hu KF 

PROVIDER: S-EPMC10621127 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature