Recruitment of pre-dementia participants: main enrollment barriers in a longitudinal amyloid-PET study.

ABSTRACT:

Background

The mismatch between the limited availability versus the high demand of participants who are in the pre-dementia phase of Alzheimer's disease (AD) is a bottleneck for clinical studies in AD. Nevertheless, potential enrollment barriers in the pre-dementia population are relatively under-reported. In a large European longitudinal biomarker study (the AMYPAD-PNHS), we investigated main enrollment barriers in individuals with no or mild symptoms recruited from research and clinical parent cohorts (PCs) of ongoing observational studies.

Methods

Logistic regression was used to predict study refusal based on sex, age, education, global cognition (MMSE), family history of dementia, and number of prior study visits. Study refusal rates and categorized enrollment barriers w

SUBMITTER: Bader I 

PROVIDER: S-EPMC10621165 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature