Sex-specific aspects in patients with oropharyngeal squamous cell carcinoma: a bicentric cohort study.

ABSTRACT:

Background

Oropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other cancer entities have revealed differences in treatment response and prognosis. However, only limited data in OPSCC according to gender and human papillomavirus (HPV) status exist. Therefore, we aimed to investigate sex-specific differences in OPSCC and how these may be distributed in relation to HPV and other risk factors.

Methods

This retrospective, bicentric study included 1629 patients with OPSCC diagnosed between 1992 and 2020. We formed subgroups based on TNM status, American Joint Cancer Committee 8^th edition (AJCC8), HPV status, treatment modality (surgery (± radio(chemo)therapy (RCT) v

SUBMITTER: Klasen C 

PROVIDER: S-EPMC10621233 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature