Noncanonical autophagy is a new strategy to inhibit HSV-1 through STING1 activation.

ABSTRACT: STING1 (stimulator of interferon response cGAMP interactor 1) plays an essential role in immune responses for virus inhibition via inducing the production of type I interferon, inflammatory factors and macroautophagy/autophagy. In this study, we found that STING1 activation could induce not only canonical autophagy but also non-canonical autophagy (NCA) which is independent of the ULK1 or BECN1 complexes to form MAP1LC3/LC3-positive structures. Whether STING1-induced NCA has similar characters and physiological functions to canonical autophagy is totally unknown. Different from canonical autophagy, NCA could increase single-membrane structures and failed to degrade long-lived proteins, and could be strongly suppressed by interrupting vacuolar-type H⁺-translocating ATPase (V-ATPa

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC10621258 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature