Impacts of Matrix Metalloproteinase 9 Genotypes on Renal Cell Carcinoma.

ABSTRACT:

Background/aim

The expression of matrix metalloproteinase 9 (MMP9) is elevated in various renal diseases, including renal cell carcinoma. However, the role of MMP9 genotype in this context remains unclear. This study aimed to investigate the association between MMP9 promoter rs3918242 genotypes and the risk of renal cell carcinoma.

Materials and methods

The MMP9 rs3918242 genotypes of 118 patients with renal cell carcinoma and 590 healthy subjects were determined using the polymerase chain reaction-restriction fragment length polymorphism method.

Results

The results indicated that individuals carrying the CT or TT genotype of MMP9 rs3918242 did not exhibit an increased risk of renal cell carcinoma compared to wild-type CC carriers (odds ratio=1.20 and 2.68, 95% confid

SUBMITTER: Liao CH 

PROVIDER: S-EPMC10621411 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature