Protective efficacy of six recombinant proteins as vaccine candidates against Echinococcus granulosus in dogs.

ABSTRACT:

Background

Cystic echinococcosis (CE) is caused by the infection of Echinococcus granulosus sensu lato (E. granulosus s.l.), one of the most harmful zoonotic helminths worldwide. Infected dogs are the major source of CE transmission. While praziquantel-based deworming is a main measure employed to control dog infections, its efficacy is at times compromised by the persistent high rate of dog re-infection and the copious discharge of E. granulosus eggs into the environment. Therefore, the dog vaccine is a welcome development, as it offers a substantial reduction in the biomass of E. granulosus. This study aimed to use previous insights into E. granulosus functional genes to further assess the protective efficacy of six recombinant proteins in dogs using a two-time injection vaccinat

SUBMITTER: Shao G 

PROVIDER: S-EPMC10621941 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature