Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation.

ABSTRACT: Encapsulation of therapeutic cells in a semipermeable device can mitigate the need for systemic immune suppression following cell transplantation by providing local immunoprotection while being permeable to nutrients, oxygen, and different cell-secreted biomolecules. However, fibrotic tissue deposition around the device has been shown to compromise the long-term function of the transplanted cells. Herein, a macroencapsulation device design that improves long-term survival and function of the transplanted cells is reported. The device is comprised of a semipermeable chitosan pouch with a tunable reservoir and molecularly engineered interface. The chitosan pouch interface decorated with 1,12-dodecanedioic acid (DDA), limits the cell adhesion and vigorous foreign body response while maintaini

SUBMITTER: Perikamana SKM 

PROVIDER: S-EPMC10622113 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature