Ontology highlight
ABSTRACT:
SUBMITTER: McGuirk JP
PROVIDER: S-EPMC10622312 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
McGuirk Joseph P JP Metheny Leland L Pineiro Luis L Litzow Mark M Rowley Scott D SD Avni Batia B Tamari Roni R Lazarus Hillard M HM Rowe Jacob M JM Sheleg Michal M Rothenstein Daniel D Halevy Nitsan N Zuckerman Tsila T
Bone marrow transplantation 20230808 11
Persistent cytopenia in the post-hematopoietic cell transplantation (HCT) setting can occur despite adequate engraftment of donor cells. PLX-R18, a placental-derived mesenchymal-like cell product, is expanded ex vivo in a 3-dimensional environment. PLX-R18 cells secrete a large array of hematopoietic factors, which promote regeneration, maturation, and differentiation of hematopoietic cells and stimulate their migration to peripheral blood. This phase 1, first-in-human study (NCT03002519), inclu ...[more]