Finding haplotypic signatures in proteins.

ABSTRACT:

Background

The nonrandom distribution of alleles of common genomic variants produces haplotypes, which are fundamental in medical and population genetic studies. Consequently, protein-coding genes with different co-occurring sets of alleles can encode different amino acid sequences: protein haplotypes. These protein haplotypes are present in biological samples and detectable by mass spectrometry, but they are not accounted for in proteomic searches. Consequently, the impact of haplotypic variation on the results of proteomic searches and the discoverability of peptides specific to haplotypes remain unknown.

Findings

Here, we study how common genetic haplotypes influence the proteomic search space and investigate the possibility to match peptides containing multiple amino aci

SUBMITTER: Vasicek J 

PROVIDER: S-EPMC10622322 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature