Immunosuppressant adherence in adult outpatient hematopoietic cell transplant recipients.

ABSTRACT:

Introduction

Medication nonadherence continues to be challenging for allogeneic hematopoietic cell transplant (HCT) recipients. The risk and severity of chronic graft-versus-host disease (GVHD) are associated with low immunosuppressant concentrations (which can be improved with model-informed precision dosing (MIPD)) and with immunosuppressant nonadherence (which can be improved with acceptable interventions).

Methods

With the goals of improving adherence and achieving therapeutic concentrations of immunosuppressants to eliminate GVHD, we characterized the feasibility of using the Medication Event Monitoring (MEMS^®) Cap in adult HCT recipients.

Results

Of the 27 participants offered the MEMS^® Cap at the time of hospital discharge, 7 (25.9%) used

SUBMITTER: McCune JS 

PROVIDER: S-EPMC10622331 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature