Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU).

ABSTRACT:

Purpose

Thrombocytopenia (platelet count < 150 × 10⁹/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients.

Methods

We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.

Results

We analysed 1166 ICU patients; the median age was 63 years an

SUBMITTER: Anthon CT 

PROVIDER: S-EPMC10622358 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature