Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes.

ABSTRACT:

Purpose

The heterogeneity in sepsis is held responsible, in part, for the lack of precision treatment. Many attempts to identify subtypes of sepsis patients identify those with shared underlying biology or outcomes. To date, though, there has been limited effort to determine overlap across these previously identified subtypes. We aimed to determine the concordance of critically ill patients with sepsis classified by four previously described subtype strategies.

Methods

This secondary analysis of a multicenter prospective observational study included 522 critically ill patients with sepsis assigned to four previously established subtype strategies, primarily based on: (i) clinical data in the electronic health record (α, β, γ, and δ), (ii) biomarker data (hyper- and hypoinfla

SUBMITTER: van Amstel RBE 

PROVIDER: S-EPMC10622359 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature