Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats.

ABSTRACT: With the large-scale vaccination of lipid nanoparticles (LNP)-based COVID-19 mRNA vaccines, elucidating the potential polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant LNP has become imminent. However, inconsistent findings were observed across very limited population-based studies. Herein we initiated a study using LNP carrier of Comirnaty^® as a representative, and simulated real-world clinical practice covering a series of time points and various doses correlated with approved LNP-delivered drugs in a rat model. We demonstrated the time- and dose-dependency of LNP-induced anti-PEG antibodies in rats. As a thymus-independent antigen, LNP unexpectedly induced isotype switch and immune memory, leading to rapid enhancement and longer lasting ti

SUBMITTER: Wang H 

PROVIDER: S-EPMC10622525 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature