Characterization of Na⁺ currents regulating intrinsic excitability of optic tectal neurons.

ABSTRACT: Developing neurons adapt their intrinsic excitability to maintain stable output despite changing synaptic input. The mechanisms behind this process remain unclear. In this study, we examined Xenopus optic tectal neurons and found that the expressions of Na_v1.1 and Na_v1.6 voltage-gated Na⁺ channels are regulated during changes in intrinsic excitability, both during development and becsuse of changes in visual experience. Using whole-cell electrophysiology, we demonstrate the existence of distinct, fast, persistent, and resurgent Na⁺ currents in the tectum, and show that these Na⁺ currents are co-regulated with changes in Na_v channel expression. Using antisense RNA to suppress the expression of specific Na_v s

SUBMITTER: Thompson AC 

PROVIDER: S-EPMC10622587 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature