Glycosyl hydrolase from Pseudomonas fluorescens inhibits the biofilm formation of Pseudomonads.

ABSTRACT: Biofilms are complex microbial communities embedded in extracellular matrix. Pathogens within the biofilm become more resistant to the antibiotics than planktonic counterparts. Novel strategies are required to encounter biofilms. Exopolysaccharides are one of the major components of biofilm matrix and play a vital role in biofilm architecture. In previous studies, a glycosyl hydrolase, PslG_PA, from Pseudomonas aeruginosa was found to be able to inhibit biofilm formation by disintegrating exopolysaccharide in biofilms. Here, we investigate the potential spectrum of PslG homologous protein with anti-biofilm activity. One glycosyl hydrolase from Pseudomonas fluorescens, PslG_PF, exhibits anti-biofilm activities and the key catalytic residues of PslG_PF</

SUBMITTER: Wang D 

PROVIDER: S-EPMC10622837 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature