MRI BrainAGE demonstrates increased brain aging in systemic lupus erythematosus patients.

ABSTRACT:

Introduction

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease affecting multiple organs in the human body, including the central nervous system. Recently, an artificial intelligence method called BrainAGE (Brain Age Gap Estimation), defined as predicted age minus chronological age, has been developed to measure the deviation of brain aging from a healthy population using MRI. Our aim was to evaluate brain aging in SLE patients using a deep-learning BrainAGE model.

Methods

Seventy female patients with a clinical diagnosis of SLE and 24 healthy age-matched control females, were included in this post-hoc analysis of prospectively acquired data. All subjects had previously undergone a 3 T MRI acquisition, a neuropsychological evaluation and a measure

SUBMITTER: Kuchcinski G 

PROVIDER: S-EPMC10622955 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature