Expression signature of human endogenous retroviruses in chronic lymphocytic leukemia.

ABSTRACT: Chronic lymphocytic leukemia (CLL) is one of the most diagnosed forms of leukemia worldwide and it is usually classified into two forms: indolent and aggressive. These two forms are characterized by distinct molecular features that drive different responses to treatment and clinical outcomes. In this context, a better understanding of the molecular landscape of the CLL forms may potentially lead to the development of new drugs or the identification of novel biomarkers. Human endogenous retroviruses (HERVs) are a class of transposable elements that have been associated with the development of different human cancers, including different forms of leukemias. However, no studies about HERVs in CLL have ever been reported so far. Here, we present the first locus-specific profiling of HERV expre

SUBMITTER: Ferlita A 

PROVIDER: S-EPMC10622969 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature