Immune cells are associated with mortality: the Health and Retirement Study.

ABSTRACT:

Introduction

Age-related immunosenescence is characterized by changes in immune cell subsets and is associated with mortality. However, since immunosenescence is associated with other concurrent age-related changes such as inflammation and multi-organ dysfunction, it is unclear whether the association between age-related immunosenescence and mortality is independent of other concurrent age-related changes. To address these limitations, we evaluated the independent association between immune cell subsets and mortality after adjustment for age-related inflammation and biologic age.

Methods

Data for this study was obtained from the 2016 interview of the Health and Retirement Study (N=6802). Cox proportional hazards regression models were used to estimate the association between

SUBMITTER: Seshadri G 

PROVIDER: S-EPMC10623116 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature