An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography.

ABSTRACT:

Background & aims

We conducted an individual patient data meta-analysis to establish stiffness cut-off values for magnetic resonance elastography (MRE) in staging liver fibrosis and to assess potential confounding factors.

Methods

A systematic review of the literature identified studies reporting MRE data in patients with NAFLD. Data were obtained from the corresponding authors. The pooled diagnostic cut-off value for the various fibrosis stages was determined in a two-stage meta-analysis. Multilevel modelling methods were used to analyse potential confounding factors influencing the diagnostic accuracy of MRE in staging liver fibrosis.

Results

Eight independent cohorts comprising 798 patients were included in the meta-analysis. The area under the receiver operating c

SUBMITTER: Liang JX 

PROVIDER: S-EPMC10623141 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature