Selective adaptation of SARS-CoV-2 Omicron under booster vaccine pressure: a multicentre observational study.

ABSTRACT:

Background

High rates of vaccination and natural infection drive immunity and redirect selective viral adaptation. Updated boosters are installed to cope with drifted viruses, yet data on adaptive evolution under increasing immune pressure in a real-world situation are lacking.

Methods

Cross-sectional study to characterise SARS-CoV-2 mutational dynamics and selective adaptation over >1 year in relation to vaccine status, viral phylogenetics, and associated clinical and demographic variables.

Findings

The study of >5400 SARS-CoV-2 infections between July 2021 and August 2022 in metropolitan New York portrayed the evolutionary transition from Delta to Omicron BA.1-BA.5 variants. Booster vaccinations were implemented during the Delta wave, yet booster breakthrough infect

SUBMITTER: Duerr R 

PROVIDER: S-EPMC10623172 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature