Streptococcus salivarius Probiotics to Prevent Acute Otitis Media in Children: A Randomized Clinical Trial.

ABSTRACT:

Importance

New approaches for the prevention of acute otitis media (AOM), the most common reason for antibiotic use in children, are needed.

Objective

To assess the efficacy of the Streptococcus salivarius K12 oral probiotics in the primary prevention of AOM.

Design, setting, and participants

This double-blind, randomized placebo-controlled clinical trial was conducted from August 1, 2020, to May 31, 2021, at 50 day care centers in the Oulu region of Finland. A total of 827 children aged 1 to 6 years attending day care were included. The exclusion criteria consisted of ongoing antimicrobial prophylaxis or immunodeficiency. The follow-up time was 6 months and was completed on May 31, 2021. Data were analyzed from October 24, 2022, to September 16, 2023, based on intent

SUBMITTER: Sarlin S 

PROVIDER: S-EPMC10623191 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature