The protective effect of allium cepa against ethylene glycol-induced kidney stones in rats.

ABSTRACT:

1background

Kidney stones is one of the serious medical conditions affecting populations worldwide. So, we aimed in this study to investigate the protective effect of allium cepa administration against KSD.

2methods

24 adult male albino rats were assigned into 3 groups; group I: control group; group II: received ethylene glycol (EG) in the drinking water for 4 weeks; and group III received EG in the drinking water plus freshly prepared allium cepa extract (ACE) for 4 weeks. Renal function tests and urine analysis were done. Tissue oxidative stress markers (SOD and MDA) were assessed, and kidney expression of SIRT-1, Beclin, LC3, osteopontin, and Regucalcin were measured by RT-qPCR. Histopathological assessment and immunohistochemistry for Bax, Beclin-1 and TNF-α were perform

SUBMITTER: Wahid RM 

PROVIDER: S-EPMC10623283 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature