White matter tracts contribute selectively to cognitive functioning in patients with glioma.

ABSTRACT:

Objective

The functional organization of white matter (WM) tracts is not well characterized, especially in patients with intrinsic brain tumors where complex patterns of tissue injury, compression, and neuroplasticity may be present. This study uses diffusion tensor imaging (DTI) to investigate the relationships between WM tract disruption and cognitive deficits in glioma patients.

Methods

Seventy-nine patients with glioma underwent preoperative DTI and neuropsychological testing. Thirteen WM tracts were reconstructed bilaterally. Fractional anisotropy and streamline number were obtained for each tract as indices of connectivity. Univariate regression models were used to model the association between WM tract connectivity and neuropsychological outcomes.

Results

Gliom

SUBMITTER: Andreoli M 

PROVIDER: S-EPMC10623310 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature