Dynamic changes of fecal microbiota in a weight-change model of Bama minipigs.

ABSTRACT:

Introduction

Obesity is closely related to gut microbiota, however, the dynamic change of microbial diversity and composition during the occurrence and development process of obesity is not clear.

Methods

A weight-change model of adult Bama pig (2 years, 58 individuals) was established, and weight gain (27 weeks) and weight loss (9 weeks) treatments were implemented. The diversity and community structures of fecal microbiota (418 samples) was investigated by using 16S rRNA (V3-V4) high-throughput sequencing.

Results

During the weight gain period (1~27 week), the alpha diversity of fecal microbiota exhibited a "down-up-down" fluctuations, initially decreasing, recovering in the mid-term, and decreasing again in the later stage. Beta diversity also significantly changed

SUBMITTER: Zeng B 

PROVIDER: S-EPMC10623433 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature