Significant variation of filamentation phenotypes in clinical Candida albicans strains.

ABSTRACT:

Introduction

Candida albicans is an opportunistic human pathogen that typically resides as part of the microbiome in the gastrointestinal and genitourinary tracts of a large portion of the human population. This fungus lacks a true sexual cycle and evolves in a largely clonal pattern. The ability to cause disease is consistent across the species as strains causing systemic infections appear across the known C. albicans intra-species clades.

Methods

In this work, strains collected from patients with systemic C. albicans infections isolated at the Nebraska Medicine clinical laboratory were typed by MLST analysis. Since the ability to form filaments has been linked to pathogenesis in C. albicans, these clinical strains, as well as a previously genoty

SUBMITTER: Brandquist ND 

PROVIDER: S-EPMC10623444 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature