Sex linked behavioral and hippocampal transcriptomic changes in mice with cell-type specific Egr1 loss.

ABSTRACT: The transcription factor EGR1 is instrumental in numerous neurological processes, encompassing learning and memory as well as the reaction to stress. Egr1 complete knockout mice demonstrate decreased depressive or anxiety-like behavior and impaired performance in spatial learning and memory. Nevertheless, the specific functions of Egr1 in distinct cell types have been largely underexplored. In this study, we cataloged the behavioral and transcriptomic character of Nestin-Cre mediated Egr1 conditional knockout (Egr1cKO) mice together with their controls. Although the conditional knockout did not change nociceptive or anxiety responses, it triggered changes in female exploratory activity during anxiety testing. Hippocampus-dependent spatial learning in the object locatio

SUBMITTER: Swilley C 

PROVIDER: S-EPMC10623684 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature