Alterations in gut microbiota and host transcriptome of patients with coronary artery disease.

ABSTRACT:

Background

Coronary artery disease (CAD) is a widespread heart condition caused by atherosclerosis and influences millions of people worldwide. Early detection of CAD is challenging due to the lack of specific biomarkers. The gut microbiota and host-microbiota interactions have been well documented to affect human health. However, investigation that reveals the role of gut microbes in CAD is still limited. This study aims to uncover the synergistic effects of host genes and gut microbes associated with CAD through integrative genomic analyses.

Results

Herein, we collected 52 fecal and 50 blood samples from CAD patients and matched controls, and performed amplicon and transcriptomic sequencing on these samples, respectively. By comparing CAD patients with health controls, we

SUBMITTER: Chen L 

PROVIDER: S-EPMC10623719 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature