Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

The relationship between aging and osteoporosis is well established. However, the relationship between the body's physiological age, i.e. epigenetic age, and osteoporosis is not known. Our goal is to analyze the bidirectional causal relationship between epigenetic clocks and osteoporosis using a bidirectional Mendelian randomization study.

Methods

We used SNPs closely associated with GrimAge, Hannum, PhenoAge, and HorvathAge in epigenetic age and SNPs closely associated with femoral neck bone mineral density, lumbar spine bone mineral density, and forearm bone mineral density as instrumental variables, respectively, using the inverse variance weighting method and several other MR methods to assess the bidirectional causal relationship between epigenetic age and os

SUBMITTER: Liang X 

PROVIDER: S-EPMC10623745 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature